Biography

Erik M. Stang, Ph.D., is a registered patent agent in the firm’s Chemical Patent Prosecution group, focusing on patent preparation, patent prosecution, and providing technical consulting for domestic and international clients in a wide array of technical areas, including pharmaceuticals (small molecules and biologics), organic synthesis, catalysis, biotechnology, polymers, inks, and nanomaterials.

Prior to joining the firm in 2014, Dr. Stang worked as a Research Investigator in oncology chemistry drug discovery at Bristol-Myers Squibb where he worked on both early and late stage research programs in the cancer therapeutic area, including protein-protein interaction inhibitors and antibody-drug conjugates featuring a variety of payloads. These medicinal chemistry programs included small molecule, millamolecular, and biologic research areas.

 Dr. Stang completed his doctoral studies at the University of Illinois Urbana-Champaign. There, he developed and applied carbon-hydrogen activation reactions in complex molecule synthesis, including the synthesis of members of the erythronolide macrolide antibiotics and dehydrogentive Diels-Alder reactions.

Education

  • University of Illinois Urbana-Champaign (Ph.D.)
    • Organic Chemistry
  • James Madison University (B.S., summa cum laude)
    • Chemistry

Admissions

  • Registered to practice before the U.S. Patent and Trademark Office

Accolades

  • Bristol-Myers Squibb Graduate Fellowship, 2010
  • R.C. Fuson Travel Award, 2010
  • Roche Excellence in Chemistry Award, 2009
  • Pfizer Graduate Fellowship, 2008
  • R.C. Fuson Graduate Fellowship, 2007
  • Roger Adams Graduate Fellowship, 2006
  • Pfizer Undergraduate Research Fellowship, 2005
  • American Institute of Chemists Award, 2005
  • National Science Foundation Research Experience for Undergraduates Fellowship, 2003

Citations

Patents:

 Borzilleri, R.M.; Perez, H.L.; Stang, E.M; Kim, K.S. U.S. Patent No. 8,889,712 B2, November 18, 2014.

Kim, K.S.; Zhang, L.; Stang, E.M. U.S. Patent No. 9,637,518 B2, May 2, 2017.

Zhang, Y; Borzilleri, R.M.; Tebben, A.J.; Stang, E.M.; Donnell, A.F.; Schroeder, G.M.; Perez, H.L.; Wei, D.D. U.S. Patent No. 9,688,694 B2, June 27, 2017.

Borzilleri, R.M.; Kim, K.S.; Perez, H.L.; Stang, E.M.; Williams, D.K.; Zhang, L. U.S. Patent No. 9,783,573 B2, October 10, 2017.

Zhang, Y; Borzilleri, R.M.; Tebben, A.J.; Stang, E.M.; Donnell, A.F.; Schroeder, G.M.; Perez, H.L.; Wei, D.D. U.S. Patent No. 9,902,740 B2, February 27, 2018.

 


Publications:

Stang, E.M.; White, M.C. “Total Synthesis and Study of 6-deoxyerythronolide B by Late-Stage C–H Oxidation.” Nature Chemistry, 2009, 1, 547-551.

Stang, E.M.; White, M.C. “On the Macrocyclization of the Erythromycin Core: Preorganization is Not Required.” Angewandte Chemie International Edition, 2011, 50, 2094-2097.

Stang, E.M.; White, M.C. “Molecular Complexity via C–H Activation: A Dehydrogenative Diels-Alder Reaction.” J. Am. Chem. Soc. 2011, 33, 14892-14895.

 Kim, K.S.; Zhang, L.; Williams, D.; Perez, H.L.; Stang, E.; Borzilleri, R.M.; Posy, S.; Lei, M.; Chaudhry, C.; Emanuel, S.; Talbot, R. “Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists” Bioorg. & Med. Chem. Lett. 2014, 24, 5022-5029.

Donnell, A.F.; Zhang, Y.; Stang, E.M.; Wei, D.D.; Tebben, A.J.; Perez, H.L.; Schroeder, G.M.; Pan, C.; Rao, C.; Borzilleri, R.M.; Vite, G.D. Gangwar, S. “Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads” Bioorg. & Med. Chem. Lett. 2017, 27, 5267-5271.

 

 


Speeches:

“Engineering Payloads for Antibody-Drug Conjugates” Bristol-Myers Squibb Lawrenceville Discovery Chemistry Seminar Series, October 2013, Lawrenceville, NJ.

“C–H Oxidation Reactions in Complex Molecule Synthesis: Application and Development” Bristol-Myers Squibb Graduate Fellowship Award Symposium, April 2011, Lawrenceville, NJ.

“Total Synthesis and Study of 6-deoxyerythronolide B via Late-Stage C–H Oxidations” 59th Natural Products Gordon Research Conference, July 2010, Tilton, NH.

“Total Synthesis and Study of 6-deoxyerythronolide B via Late-Stage C–H Oxidations” 23rd Annual Allerton Research Conference, 2009, Monticello, IL.

 “Total Synthesis and Study of 6-deoxyerythronolide B via Late-Stage C–H Oxidations” Roche Symposium: Excellence in Chemistry, 2009, Nutley, NJ.

"Cyclopropane Fragmentation Strategies for the Assembly of Nitrogenous Heterocycles" ACS National Meeting, Chemical Education Session, August 28th 2005, Washington, DC.

"Cyclopropane Fragmentation Strategies for the Assembly of Nitrogenous Heterocycles" Pfizer Global Research & Development, Summer Undergraduate Research Fellowship Program, September 30, 2005, Groton, CT.

 “Synthesis of Complex Metal Oxides via Molten Hydroxide Fluxes” JMU National Science Foundation Research Experience for Undergraduates, August 5, 2004, Harrisonburg, VA.

Professional Affiliations

  • American Chemical Society

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