Dong Chen, Ph.D., is a patent agent in the firm’s Chemical Patent Prosecution group, preparing and prosecuting U.S. patent applications. His practice covers a wide variety of technical areas, including biotechnology, pharmaceuticals (small molecules and biologics), and medical devices.
Prior to joining the firm in 2015, Dr. Chen was a research assistant professor at Northwestern University in Chicago, where he discovered the signaling mechanism leading to excess aromatase and estrogen production in breast cancer.
During his postdoctoral training at Joslin Diabetes Center and Harvard Medical School, Dr. Chen studied the role of phosphoinositide 3-kinase, a critical insulin signaling molecule, in regulating insulin sensitivity in mice under both normal body weight and obesity conditions.
Dr. Chen conducted his doctoral research on insulin signaling pathway and hyperosmolarity signaling pathway, which activate glucose transport via distinct mechanisms in fat cells.
- University of Iowa (Ph.D.)
- Molecular Biology
- Fudan University (B.S.)
- Registered to practice before the U.S. Patent and Trademark Office
- “Weight gain increases human aromatase expression in mammary gland,” Molecular and Cellular Endocrinology, 2012, 355(1):114-20 (PMID: 22342815).
- “JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters,” Molecular Endocrinology, 2011, 25(5):767-775 (PMID: 21393445).
- “Regulation of breast cancer-associated aromatase promoters,” Cancer Letters, 2009, 273(1):15-27 (PMID: 18614276).
- “PGE2 induces breast cancer-related aromatase promoters via activation of p38 and JNK in adipose fibroblasts,” Cancer Research, 2007, 67 (18): 8914-8922 (PMID: 17875734).
- “BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells,” Journal of Clinical Endocrinology & Metabolism, 2006, 91 (11): 4514-4519 (PMID: 16940443).
- “p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity,” Molecular and Cellular Biology, 2004, 24(1): 320-329 (PMID: 14673165).